期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 212, 期 6, 页码 865-874出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20142318
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资金
- Wellcome Trust [098051]
- National Natural Science Foundation of China [31370904, 30972691]
- Shanghai Science and Technology Development Fund [10QA1405900]
- Training Program of the Excellent Young Talents of the Shanghai Municipal Health System [XYQ20110115]
- Shanghai Municipal Science and Technology Foundation [11JC1410802]
Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in similar to 28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.
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