期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 284, 期 1, 页码 E96-E101出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00316.2002
关键词
gene expression; cytochrome c; cytochrome oxidase; skeletal muscle
资金
- NATIONAL INSTITUTE ON AGING [R56AG000425, R37AG000425, R01AG000425] Funding Source: NIH RePORTER
- NIA NIH HHS [AG-00425, AG-00078] Funding Source: Medline
Previous studies have indicated that exercise acutely induces large increases in uncoupling protein-3 (UCP3) in skeletal muscle, whereas endurance training results in marked decreases in muscle UCP3. Because UCP3 expression appears to be regulated by the same mechanism as other mitochondrial constituents, it seemed unlikely that exercise would result in such large and divergent changes in mitochondrial composition. The purpose of this study was to test the hypothesis that major changes in UCP3 protein concentration do not occur independently of mitochondrial biogenesis and that UCP3 increases as a component of the exercise-induced increase in mitochondria. We found a large increase in UCP3 mRNA immediately and 3 h after a bout of swimming. UCP3 protein concentration was increased similar to35% 18 h after a single exercise bout, similar to63% after 3 days, and similar to84% after 10 days of exercise. These increases in UCP3 roughly paralleled those of other mitochondrial marker proteins. Our results are consistent with the interpretation that endurance exercise induces an adaptive increase in mitochondria that have a normal content of UCP3.
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