期刊
CELL
卷 157, 期 1, 页码 26-40出版社
CELL PRESS
DOI: 10.1016/j.cell.2014.03.005
关键词
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资金
- Basic Science Research Program [2013R1A1A1009625]
- Bio and Medical Technology Development Program through NRF [2010-0020232]
- Korean government (MSIP)
- Autism Speaks [7109]
- Canadian Institutes of Health Research [MOP114994]
- Wellcome Trust Programme [085314/Z/08/Z]
- ERC [322817]
- National Research Foundation of Korea [2010-0020232] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- European Research Council (ERC) [322817] Funding Source: European Research Council (ERC)
The subcellular position of a protein is a key determinant of its function. Mounting evidence indicates that RNA localization, where specific mRNAs are transported subcellularly and subsequently translated in response to localized signals, is an evolutionarily conserved mechanism to control protein localization. On-site synthesis confers novel signaling properties to a protein and helps to maintain local proteome homeostasis. Local translation plays particularly important roles in distal neuronal compartments, and dysregulated RNA localization and translation cause defects in neuronal wiring and survival. Here, we discuss key findings in this area and possible implications of this adaptable and swift mechanism for spatial control of gene function.
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