期刊
NATURE GENETICS
卷 33, 期 1, 页码 19-20出版社
NATURE AMERICA INC
DOI: 10.1038/ng1054
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资金
- CENTER FOR INFORMATION TECHNOLOGY [Z01CT000261, ZIACT000261] Funding Source: NIH RePORTER
To evaluate the timing of mutations in BRAF (v-raf murine sarcoma viral oncogene homolog B1) during melanocytic neoplasia, we carried out mutation analysis on microdissected melanoma and nevi samples. We observed mutations resulting in the V599E amino-acid substitution in 41 of 60 (68%) melanoma metastases, 4 of 5 (80%) primary melanomas and, unexpectedly, in 63 of 77 (82%) nevi. These data suggest that mutational activation of the RAS/RAF/MAPK pathway in nevi is a critical step in the initiation of melanocytic neoplasia but alone is insufficient for melanoma tumorigenesis.
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