期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 22, 期 5-8, 页码 903-905出版社
MARCEL DEKKER INC
DOI: 10.1081/NCN-120022682
关键词
prodrug; phosphotriester; AZT; HIV
Synthesis and biological activities of several phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and aryl residues derived from L-tyrosine are reported. All compounds showed marked anti-HIV activity in thymidine kinase-deficient CEM cells demonstrating their ability to deliver intracellularly the parent 5'-mononucleotide.
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