期刊
ANDROLOGIA
卷 48, 期 1, 页码 20-28出版社
WILEY
DOI: 10.1111/and.12405
关键词
Bilateral nerve-sparing radical prostatectomy; erectile dysfunction sexual (penile) rehabilitation; meta-analysis; phosphodiesterase type 5 inhibitors
类别
We carried out a systematic review and meta-analysis to assess the efficacy and safety of phosphodiesterase type 5 (PDE5) inhibitors for treating erectile dysfunction (ED) after bilateral nerve-sparing radical prostatectomy (BNSRP). A literature review was performed to identify all published randomised double-blind, placebo-controlled trials of PDE5 inhibitors for the treatment of ED after BNSRP. The search included the following databases: MEDLINE, EMBASE and the Cochrane Controlled Trials Register. The reference lists of the retrieved studies were also investigated. Six publications involving a total of 1678 patients were used in the analysis, including six RCTs that compared PDE5 inhibitors (tadalafil, sildenafil, avanafil and vardenafil) with placebo. Co-primary efficacy end points: International Index of Erectile Function-Erectile Function (IIEF-EF) domain score [the standardised mean difference (SMD)=4.04, 95% confidence interval (CI)=2.87-5.22, P<0.00001]; successful vaginal penetration (SEP2) [the odds ratio (OR)=14.87, 95%CI=4.57-48.37, P<0.00001]; and successful intercourse (SEP3) (OR=47, 95%CI=3-13.98, P<0.00001) indicated that PDE5 inhibitors was more effective than the placebo. Specific adverse events with PDE5 inhibitors included headache (12.08%), dyspepsia (6.76%) and flushing (6.52%), which were significantly less likely to occur with placebo. This meta-analysis indicates that PDE5 inhibitors to be an effective and well-tolerated treatment for ED after BNSRP.
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