期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 284, 期 1, 页码 E76-E89出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00234.2002
关键词
muscle protein synthesis; muscle protein breakdown; stable isotopic tracers
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000073] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR045382] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK038010] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG024832] Funding Source: NIH RePORTER
- NCRR NIH HHS [M01 RR-00073] Funding Source: Medline
- NIAMS NIH HHS [R01-AR-45382] Funding Source: Medline
- NIA NIH HHS [P30 AG024832] Funding Source: Medline
- NIDDK NIH HHS [R01-DK-38010] Funding Source: Medline
The purpose of this study was to determine if the acute anabolic muscle response to resistance exercise and essential amino acids (EAA) reflects the response over 24 h. Seven subjects participated in the following two 24-h studies: 1) resting (REST) and 2) rest plus resistance exercise and consumption of EAA (ES). Net balance (NB) across the leg was determined for four amino acids. [C-13(6)] phenylalanine was infused to determine mixed muscle fractional synthetic rate (FSR). Twenty-four-hour FSR was significantly greater for ES than for REST (P = 0.003). Exchange of phenylalanine across the leg was -194 +/- 74 (SE) mg for ES and -371 +/- 88 mg for REST (P = 0.07) over 24 h and 229 +/- 42 mg (ES) and 28 +/- 15 mg (REST; P < 0.01) over 3 h corresponding to exercise and EAA consumption for ES. The difference in phenylalanine exchange between REST and ES was not different for measurements over 24 and 3 h. Increases in NB during ES were primarily the result of increases in protein synthesis. Results for other amino acids were similar. The acute anabolic response of muscle to EAA intake and exercise is additive to the response at rest and thus reflects the 24-h response.
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