期刊
CELL
卷 158, 期 5, 页码 1072-1082出版社
CELL PRESS
DOI: 10.1016/j.cell.2014.07.024
关键词
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资金
- G. Harold and Leila Y. Mathers Foundation
- Howard Hughes Medical Institutes (HHMI)
- HHMI fellow of the Damon Runyon Cancer Research Foundation [DRG-1964-08]
- NIH Pathway to Independence Award [K99 GM098600]
[GAR(+)] is a protein-based element of inheritance that allows yeast ( Saccharomyces cerevisiae) to circumvent a hallmark of their biology: extreme metabolic specialization for glucose fermentation. When glucose is present, yeast will not use other carbon sources. [GAR(+)] allows cells to circumvent this glucose repression.'' [GAR(+)] is induced in yeast by a factor secreted by bacteria inhabiting their environment. We report that de novo rates of [GAR(+)] appearance correlate with the yeast's ecological niche. Evolutionarily distant fungi possess similar epigenetic elements that are also induced by bacteria. As expected for a mechanism whose adaptive value originates from the selective pressures of life in biological communities, the ability of bacteria to induce [GAR(+)] and the ability of yeast to respond to bacterial signals have been extinguished repeatedly during the extended monoculture of domestication. Thus, [GAR(+)] is a broadly conserved adaptive strategy that links environmental and social cues to heritable changes in metabolism.
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