期刊
CELL
卷 158, 期 5, 页码 1083-1093出版社
CELL PRESS
DOI: 10.1016/j.cell.2014.07.025
关键词
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资金
- G. Harold and Leila Y. Mathers Foundation
- Howard Hughes Medical Institute (HHMI
- HHMI fellow of the Damon Runyon Cancer Research Foundation [DRG-1964-08]
- NIH Pathway to independence award [K99 GM098600]
In experimental science, organisms are usually studied in isolation, but in the wild, they compete and cooperate in complex communities. We report a system for cross-kingdom communication by which bacteria heritably transform yeast metabolism. An ancient biological circuit blocks yeast from using other carbon sources in the presence of glucose. [GAR(+)], a protein-based epigenetic element, allows yeast to circumvent this glucose repression'' and use multiple carbon sources in the presence of glucose. Some bacteria secrete a chemical factor that induces [GAR(+)]. [GAR(+)] is advantageous to bacteria because yeast cells make less ethanol and is advantageous to yeast because their growth and long-term viability is improved in complex carbon sources. This cross-kingdom communication is broadly conserved, providing a compelling argument for its adaptive value. By heritably transforming growth and survival strategies in response to the selective pressures of life in a biological community, [GAR(+)] presents a unique example of Lamarckian inheritance.
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