期刊
CELL
卷 155, 期 2, 页码 357-368出版社
CELL PRESS
DOI: 10.1016/j.cell.2013.09.008
关键词
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资金
- Centre for Biomedical Genetics (CBG)
- European Research Council [EU/232814-StemCellMark, EU/Health-F4-2007-200720]
- National Research Foundation of Korea [NRF2011-357-C00093]
- Wellcome Trust [097922/C/11/Z]
- EU Marie Curie Fellowship [EU/236954-ICSC-Lgr5, EU/300686-InfO]
- Cancer Genomics Center (CGCII)
- TI Pharma [T3-106, DK094989, 2P30 DK052574]
- Wellcome Trust [097922/C/11/Z] Funding Source: Wellcome Trust
Proliferation of the self-renewing epithelium of the gastric corpus occurs almost exclusively in the isthmus of the glands, from where cells migrate bidirectionally toward pit and base. The isthmus is therefore generally viewed as the stem cell zone. We find that the stem cell marker Troy is expressed at the gland base by a small subpopulation of fully differentiated chief cells. By lineage tracing with a Troy-eGFP-ires-CreERT2 allele, single marked chief cells are shown to generate entirely labeled gastric units over periods of months. This phenomenon accelerates upon tissue damage. Troy(+) chief cells can be cultured to generate long-lived gastric organoids. Troy marks a specific subset of chief cells that display plasticity in that they are capable of replenishing entire gastric units, essentially serving as quiescent reserve stem cells. These observations challenge the notion that stem cell hierarchies represent a one-way street.
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