期刊
CELL
卷 152, 期 6, 页码 1298-1307出版社
CELL PRESS
DOI: 10.1016/j.cell.2013.02.012
关键词
-
资金
- NIH
- California Institute for Regenerative Medicine
In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code-how objects are placed and later searched for and retrieved. Long noncoding RNAs (IncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. IncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations.
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