期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 144, 期 1-2, 页码 46-52出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2003.08.029
关键词
acetylcholine; choline acetyltransferase; T lymphocyte; apelin; APJ; interleukin-2
We investigated the effects of apelin, an immunologically active peptide ligand for orphan receptor APJ, on acetylcholine (ACh) synthesis in MOLT-3 human leukemic T cells. We initially confirmed expression of AN mRNA in several human T- and B-cell lines by reverse transcription-polymerase chain reaction (RT-PCR). We also found that in phytohemagglutinin (PHA)-stimulated MOLT-3 cells, an active apelin fragment, apelin-13, down-regulates expression of choline acetyltransferase (ChAT) mRNA and significantly reduces ChAT activity and cellular ACh content and release. It thus appears that apelin inhibits lymphocytic cholinergic activity via APJ during immunological responses. (C) 2003 Elsevier B.V. All rights reserved.
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