期刊
CELL
卷 152, 期 1-2, 页码 352-364出版社
CELL PRESS
DOI: 10.1016/j.cell.2012.10.054
关键词
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资金
- NIH [GM60398]
- NSF [0701745, 1121245]
- Fred Eiserling and Judith Lengyel Graduate Doctorate Fellowship
- US Public Health Service National Research Service Award [GM07104]
- UCLA Dissertation Year Fellowship
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1121245] Funding Source: National Science Foundation
Cytosine methylation is involved in various biological processes such as silencing of transposable elements (TEs) and imprinting. Multiple pathways regulate DNA methylation in different sequence contexts, but the factors that regulate DNA methylation at a given site in the genome largely remain unknown. Here we have surveyed the methylomes of a comprehensive list of 86 Arabidopsis gene silencing mutants by generating single-nucleotide resolution maps of DNA methylation. We find that DNA methylation is site specifically regulated by different factors. Furthermore, we have identified additional regulators of DNA methylation. These data and analyses will serve as a comprehensive community resource for further understanding the control of DNA methylation patterning.
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