期刊
CELL
卷 153, 期 1, 页码 56-69出版社
CELL PRESS
DOI: 10.1016/j.cell.2013.03.004
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R01 CA076120, R01 CA068490] Funding Source: Medline
Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metabolism. This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, FH, and IDH can result in cancer and, more broadly, for how alterations in metabolism and nutrition might contribute to disease. Here, we review literature pertinent to hypothetical connections between metabolic and epigenetic states in eukaryotic cells.
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