A Template for New Drugs against Alzheimer's Disease

Alzheimer's disease (AD) is associated with the deposition of beta-amyloid (A beta) plaques in the brain. In this issue, by cleverly processing patient samples, Lu et al. define a novel structural model of A beta fibrils from AD brain, revealing surprising differences from in vitro fibrils. These findings may lead to structure-specific inhibitors and more selective amyloid-imaging methods.