期刊
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
卷 26, 期 11, 页码 1136-1142出版社
SPRINGER
DOI: 10.1007/BF03345264
关键词
hyperparathyroidism; diabetes; glucose intolerance; insulin resistance; cardiovascular diseases
The derangement of glucose metabolism is found frequently in all forms of hyperparathyroidism. Both-in primary (PHPT) and secondary hyperparathyroidism (SHRT) PTH excess is thought to be involved in deteriorating insulin sensitivity and secretion though their different clinical and pathophysiological conditions. In PHPT these abnormalities are related to a high frequency of Type 2 diabetes mellitus and also impaired glucose tolerance according to recent clinical studies, without differences between symptomatic and asymptomatic clinical presentation. In chronic renal failure (CRF), the disorders of glucose metabolism due to SHIRT do not bear an increased risk for diabetes whereas they seem to be involved in the progression of atherosclerotic vascular damage which connotes CRF. Moreover, clinical and experimental studies have shown that vitamin D deficiency associated with glucose metabolism abnormalities favors the development of the metabolic syndrome. The potential for metabolic and cardiovascular harm related to hyperparathyroidism, especially PHRT, is the most interesting issue for clinical endocrinologists. This short review of the clinical and pathophysiological data of literature on glucose homeostasis disorders in hyperparathyroidism focuses on its potential clinical and therapeutic impact, particularly in the management of PHPT. (C) 2003, Editrice Kurtis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据