期刊
NATURE IMMUNOLOGY
卷 4, 期 11, 页码 1083-1092出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni984
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- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P01AI039646, R01AI035304] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [N01AR062227] Funding Source: NIH RePORTER
- NHLBI NIH HHS [N01-HV-281831] Funding Source: Medline
- NIAID NIH HHS [AI35304, P01-AI39646] Funding Source: Medline
- NIAMS NIH HHS [AR44656, N01-AR-6-2227] Funding Source: Medline
- NIH HHS [A1/GF41520-01] Funding Source: Medline
Leukocyte functional antigen 1 (LFA-1), with intercellular adhesion molecule ligands, mediates T cell adhesion, but the signaling pathways and functional effects imparted by LFA-1 are unclear. Here, intracellular phosphoprotein staining with 13-dimensional flow cytometry showed that LFA-1 activation induced phosphorylation of the 2 integrin chain and release of Jun-activating binding protein 1 (JAB-1), and mediated signaling of kinase Erk1/2 through cytohesin-1. Dominant negatives of both JAB-1 and cytohesin-1 inhibited interleukin 2 production and impaired T helper type 1 differentiation. LFA-1 stimulation lowered the threshold of T cell activation. Thus, LFA-1 signaling contributes to T cell activation and effects T cell differentiation.
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