期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 144, 期 1-2, 页码 139-142出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2003.08.042
关键词
amyotrophic lateral sclerosis; monocyte chemoattractant protein-1; microglia; cerebrospinal fluid; ELISA
Autopsy studies and animal experiments suggest that microglial inflammation contributes to the pathogenesis of amyotrophic lateral sclerosis (ALS). Monocyte-chemoattractant protein (MCP-1) might play an important role in microglial recruitment. We studied MCP-1 levels in sera and cerebrospinal fluid of 29 ALS patients and compared the results with 11 control patients with tension headache. The MCP-1 level was determined using enzyme-linked immunosorbent assays (ELISA). A significant increase in cerebrospinal fluid MCPA level but not serum level was seen in the patients with ALS compared to the control subjects. These results suggest that cerebrospinal fluid MCP-1 activity may be a sensitive marker for neuroinflammation in ALS useful for monitoring treatment trials in ALS. (C) 2003 Elsevier B.V All rights reserved.
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