期刊
PEPTIDES
卷 24, 期 11, 页码 1655-1667出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2003.08.024
关键词
cathelicidin; cystatin; antimicrobial peptide; HFIAP; hagfish; Myxine; agnatha; GALT; jaw hypothesis; innate immunity; indel
Three potent broad-spectrum antimicrobial peptides (HFIAP-1, -2, and -3) isolated from intestinal tissues of Myxine glutinosa (Atlantic hagfish) are identified as ancient members of the cathelicidin family of antimicrobial peptides, hitherto known only from mammals. In situ hybridization reveals that HFIAPs are produced in nests of myeloid cells within the loose connective tissue of the gut wall, a tissue reminiscent of both gut-associated lymphoid tissue (GALT) and vertebrate spleen. We suggest that this tissue organization provides local defense of the hagfish gastrointestinal tract via innate immunity and possibly served as the architectural plan upon which the adaptive immune system evolved. (C) 2003 Elsevier Inc. All rights reserved.
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