期刊
CELL
卷 148, 期 3, 页码 583-595出版社
CELL PRESS
DOI: 10.1016/j.cell.2011.12.022
关键词
-
资金
- NIH [5R01MH086920, 1RO1 DA031389]
- Nakajima Foundation
Behavior cannot be predicted from a connectome'' because the brain contains a chemical map'' of neuromodulation superimposed upon its synaptic connectivity map. Neuromodulation changes how neural circuits process information in different states, such as hunger or arousal. Here we describe a genetically based method to map, in an unbiased and brain-wide manner, sites of neuromodulation under different conditions in the Drosophila brain. This method, and genetic perturbations, reveal that the well-known effect of hunger to enhance behavioral sensitivity to sugar is mediated, at least in part, by the release of dopamine onto primary gustatory sensory neurons, which enhances sugar-evoked calcium influx. These data reinforce the concept that sensory neurons constitute an important locus for state-dependent gain control of behavior and introduce a methodology that can be extended to other neuro-modulators and model organisms.
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