期刊
CELL
卷 149, 期 2, 页码 274-293出版社
CELL PRESS
DOI: 10.1016/j.cell.2012.03.017
关键词
-
资金
- National Institutes of Health
- Howard Hughes Medical Institute
- Department of Defense
- Keck Foundation
- Whitehead Institute
- Canadian Institutes of Health Research
- Les Fonds de la Recherche en Sante du Quebec
The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据