期刊
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
卷 82, 期 12, 页码 1080-1085出版社
WILEY
DOI: 10.1046/j.1600-0412.2003.00187.x
关键词
75-g oral glucose tolerance test; carbohydrate intake; gestational diabetes mellitus; glucose-fatty acid (Randle) cycle; insulinogenic index
Objective. We verified whether a misdiagnosis of gestational diabetes mellitus can result in pregnant women when glucose tolerance has deteriorated after a low-carbohydrate meal, and tried to elucidate the mechanism behind the different outcome of the test. Study design. Twenty-seven pregnant women were given directions for their evening meal the day before each of two 75-g oral glucose tolerance tests (OGTT). The evening meal was either a low-carbohydrate meal (carbohydrate, 6.7%; Low), or a high-carbohydrate meal (carbohydrate, 85.7%; High). Results. The OGTT showed that the glucose tolerance was significantly impaired after Low than after High, with a significant increase of fasting plasma non-esterified fatty acids (NEFA) level. Moreover, the insulinogenic index (I-I) after High significantly decreased than that after Low. Conclusions. The present data suggests that there is a risk of misdiagnosis of impaired glucose tolerance with only one intake of this extremely low-carbohydrate meal on the evening before testing. The decrease of insulin secretion and the activation of glucose-fatty acid cycle may be considered as the mechanism.
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