期刊
DEVELOPMENTAL DYNAMICS
卷 228, 期 4, 页码 623-629出版社
WILEY-LISS
DOI: 10.1002/dvdy.10403
关键词
Merkel cell; NT-3; TrkC; p75NTR; neural crest; mechanoreceptor
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038500] Funding Source: NIH RePORTER
- NINDS NIH HHS [NS38500] Funding Source: Medline
- PHS HHS [1F05-11111-02] Funding Source: Medline
Merkel cells are sensory cells of neural crest origin. Because little is known about the mechanisms that direct their differentiation, we have investigated the potential role of a candidate regulatory factor, neurotrophin-3 (NT-3). At embryonic day 16.5 (E 16.5), neither INT-3 nor its primary receptors, TrkC and p75NTR are expressed by Merkel cells in the murine whisker. At the time of birth, however, Merkel cells are immunoreactive for NT-3, TrkC and p75NTR. In TrkC null and NT-3 null mice, Merkel cells differentiate initially, but undergo apoptosis perinatally. These results show that NT-3 signaling is not required for the differentiation of Merkel cells, but that it is essential for their postnatal survival. (C) 2003 Wiley-Liss, Inc.
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