期刊
PEPTIDES
卷 24, 期 12, 页码 1955-1961出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2003.10.003
关键词
neurotensin; beta-lactotensin; beta-lactoglobulin; cholesterol; NT2-receptor; levocabastine; dopamine; raclopride
beta-Lactotensin, a neurotensin NT2 agonist derived from beta-lactoglobulin, has hypocholesterolemic activity after administration for 2 days at a dose of 30 mg/kg (i.p.) or 100 mg/kg (p.o.) for 2 days in mice fed a high-cholesibrol/cholic acid diet. The onset of hypocholesterolemic activity of beta-lactotensin was observed 90 min after a single i.p. or p.o. administration at the same dose as described above. Neurotensin also induced hypocholesterolemic activity 90 min after single i.p. administration at a dose of 2 mug per mouse but was ineffective after oral administration. The rapid onset of hypocholesterolemic activities of beta-lactotensin and eurotensin was blocked by levocabastine (50 mug/kg), an NT2 antagonist, and raclopride (0.5 mg/kg), a dopamine D-2 antagonist. (C) 2003 Elsevier Inc. All rights reserved.
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