期刊
CELL
卷 151, 期 6, 页码 1163-1167出版社
CELL PRESS
DOI: 10.1016/j.cell.2012.11.012
关键词
-
资金
- National Institutes of Health
- Cystic Fibrosis Foundation Therapeutics
All cellular proteins are subject to quality control decisions,'' which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated degradation (ERAD).
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