期刊
CELL
卷 150, 期 6, 页码 1249-1263出版社
CELL PRESS
DOI: 10.1016/j.cell.2012.08.015
关键词
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资金
- NIH [AI078897, AI069259, 5T32-HL07623-20, CA069212]
- Samsung Scholarship
- Armenise-Harvard Foundation
- Canadian Institutes of Health Research
- Overseas Biomedical Fellowship from the National Health and Medical Research Council of Australia
A defining feature of vertebrate immunity is the acquisition of immunological memory, which confers enhanced protection against pathogens by mechanisms that are incompletely understood. Here, we compared responses by virus-specific naive T cells (T-N) and central memory T cells (T-CM) to viral antigen challenge in lymph nodes (LNs). In steady-state LNs, both T cell subsets localized in the deep T cell area and interacted similarly with antigen-presenting dendritic cells. However, upon entry of lymph-borne virus, only T-CM relocalized rapidly and efficiently toward the outermost LN regions in the medullary, interfollicular, and subcapsular areas where viral infection was initially confined. This rapid peripheralization was coordinated by a cascade of cytokines and chemokines, particularly ligands for T-CM-expressed CXCR3. Consequently, in vivo recall responses to viral infection by CXCR3-deficient T-CM were markedly compromised, indicating that early antigen detection afforded by intranodal chemokine guidance of T-CM is essential for efficient antiviral memory.
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