期刊
CELL
卷 151, 期 6, 页码 1243-1255出版社
CELL PRESS
DOI: 10.1016/j.cell.2012.10.045
关键词
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资金
- NIH [GM59708]
- NSF [0923810, 0900544]
- DOD [W81XWH-10-1-0122]
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [0900544] Funding Source: National Science Foundation
Genome duality in ciliated protozoa offers a unique system to showcase their epigenome as a model of inheritance. In Oxytricha, the somatic genome is responsible for vegetative growth, whereas the germline contributes DNA to the next sexual generation. Somatic nuclear development removes all transposons and other so-called junk'' DNA, which comprise similar to 95% of the germline. We demonstrate that Piwi-interacting small RNAs (piRNAs) from the maternal nucleus can specify genomic regions for retention in this process. Oxytricha piRNAs map primarily to the somatic genome, representing the similar to 5% of the germline that is retained. Furthermore, injection of synthetic piRNAs corresponding to normally deleted regions leads to their retention in later generations. Our findings highlight small RNAs as powerful transgenerational carriers of epigenetic information for genome programming.
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