期刊
CELL
卷 146, 期 3, 页码 353-358出版社
CELL PRESS
DOI: 10.1016/j.cell.2011.07.014
关键词
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资金
- Canadian Institutes of Health Research
- Human Frontier Science Program
- Istituto Toscano Tumori
- American Italian Cancer Foundation
- Leukemia & Lymphoma Society
- NHMRC
- NIH [R01 CA-82328-09]
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs talk to each other using microRNA response elements (MREs) as letters of a new language. We propose that this competing endogenous RNA (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
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