期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 27, 期 1, 页码 41-47出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0927-7765(02)00041-3
关键词
adhesion; adsorption; Derjaguin-Landau-Verwey-Overbeek; ion-penetrable
The long-range : forces controlling cell or bacteria adsorption onto substrates are governed by electrostatic interactions. In this paper we use a simple mean field model (Debye-Huckel) to examine the interactions between cells and surfaces. We model the cell interface as an ion-penetrable, charge-regulating layer, thereby accounting for the finite thickness of the cell's extra-cellular (glycocalyx) layer. We find that charge regulation leads to several nonintuitive trends regarding the repulsion between a cell and similarly charged substrates: (I) instead of increasing monotonically with decreasing cell-substrate separation, the pressure varies non-monotonically, and (II) instead of monotonically decreasing the repulsion (at contact) between the cell and the substrate, there is a regime where adding salt leads to an increase in the repulsion. (C) 2002 Elsevier Science B.V. All rights reserved.
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