期刊
CELL
卷 144, 期 1, 页码 16-26出版社
CELL PRESS
DOI: 10.1016/j.cell.2010.11.056
关键词
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资金
- Agencia Nacional de Promocion de Ciencia y Tecnologia of Argentina
- Universidad de Buenos Aires
- European Alternative Splicing Network (EURASNET)
- Consejo Nacional de Investigaciones Cientificas y Tecnicas of Argentina (CONICET)
- National Institutes of Health (NIH), NCI, Center for Cancer Research
Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced.
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