期刊
CELL
卷 146, 期 6, 页码 866-872出版社
CELL PRESS
DOI: 10.1016/j.cell.2011.08.042
关键词
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资金
- PHS [5T32CA09151]
- NIH [HL096113, HL100397, AG020961, AG009521]
- JDRF [34-2008-623]
- CIRM [RT1-01001, RB1-01292]
- Baxter Foundation
- NCI
The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of demethylating DNA and activating genes. Further experiments, however, unearthed an unexpectedly complex process, entailing both passive and active mechanisms of DNA demethylation by the ten-eleven translocation (TET) and AID/APOBEC families of enzymes. The consensus emerging from these studies is that removal of cytosine methylation in mammalian cells can occur by DNA repair. These reports highlight that in certain contexts, DNA methylation is not fixed but dynamic, requiring continuous regulation.
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