期刊
CELL
卷 145, 期 7, 页码 1023-1035出版社
CELL PRESS
DOI: 10.1016/j.cell.2011.05.026
关键词
-
资金
- National Institutes of Health [RO1-GM083348, R21CA124688]
- European Research Council
- Agence de Nationale
- Biomedical Research Council
- National Medical Research Council, Singapore
- Institute of Medical Biology
- Genome Institute of Singapore of the Agency for Science, Technology, and Research, Singapore
Barrett's esophagus is an intestine-like metaplasia and precursor of esophageal adenocarcinoma. Triggered by gastroesophageal reflux disease, the origin of this metaplasia remains unknown. p63-deficient mice, which lack squamous epithelia, may model acid-reflux damage. We show here that p63 null embryos rapidly develop intestine-like metaplasia with gene expression profiles similar to Barrett's metaplasia. We track its source to a unique embryonic epithelium that is normally undermined and replaced by p63-expressing cells. Significantly, we show that a discrete population of these embryonic cells persists in adult mice and humans at the squamocolumnar junction, the source of Barrett's metaplasia. We show that upon programmed damage to the squamous epithelium, these embryonic cells migrate toward adjacent, specialized squamous cells in a process that may recapitulate early Barrett's. Our findings suggest that certain precancerous lesions, such as Barrett's, initiate not from genetic alterations but from competitive interactions between cell lineages driven by opportunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据