期刊
CELL
卷 144, 期 2, 页码 214-226出版社
CELL PRESS
DOI: 10.1016/j.cell.2010.12.026
关键词
-
资金
- CNRS
- Ministere de l'Enseignement Superieur
- Association pour la Recherche sur le Cancer
- Agence Nationale de la Recherche
- Fondation de la Recherche Medicale
- Human Frontier Science Program Organization
- European Union
- European Research Council [ERC-2008-AdG No 232947]
- Indo-French Centre for Promotion of Advanced Research
- Ministere de l'Enseignement Superieur, ACI BCMS
In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA. Both clusters are repressed by Polycomb group (PcG) proteins. Here, we show that genes of the two Hox complexes can interact within nuclear PcG bodies in tissues where they are corepressed. This colocalization increases during development and depends on PcG proteins. Hox gene contacts are conserved in the distantly related Drosophila virilis species and they are part of a large gene interaction network that includes other PcG target genes. Importantly, mutations on one of the loci weaken silencing of genes in the other locus, resulting in the exacerbation of homeotic phenotypes in sensitized genetic backgrounds. Thus, the three-dimensional organization of Polycomb target genes in the cell nucleus stabilizes the maintenance of epigenetic gene silencing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据