期刊
CELL
卷 144, 期 6, 页码 910-925出版社
CELL PRESS
DOI: 10.1016/j.cell.2011.01.030
关键词
-
资金
- NIH [1DP2 OD006481-01, 1DP1OD003936, DP1 OD00344, RC2 HL102815, RL1 DE019021]
- NSF [IOS 1021675]
- NIH/NCI Physical Sciences Oncology Center at MIT [U54CA143874]
- Ellison Medical Foundation
- Howard Hughes Medical Institute
Cellular decision making is the process whereby cells assume different, functionally important and heritable fates without an associated genetic or environmental difference. Such stochastic cell fate decisions generate nongenetic cellular diversity, which may be critical for metazoan development as well as optimized microbial resource utilization and survival in a fluctuating, frequently stressful environment. Here, we review several examples of cellular decision making from viruses, bacteria, yeast, lower metazoans, and mammals, highlighting the role of regulatory network structure and molecular noise. We propose that cellular decision making is one of at least three key processes underlying development at various scales of biological organization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据