期刊
CELL
卷 144, 期 6, 页码 860-863出版社
CELL PRESS
DOI: 10.1016/j.cell.2011.03.007
关键词
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资金
- National Center for Research Resources [RR031228]
- National Institute of General Medical Sciences [GM076547, GM070743, GM085764]
- Department of Defense [W911SR-07-C-0101]
- Luxembourg strategic partnership
A major difficulty in the analysis of complex biological systems is dealing with the low signal-to-noise inherent to nearly all large biological datasets. We discuss powerful bioinformatic concepts for boosting signal-to-noise through external knowledge incorporated in processing units we call filters and integrators. These concepts are illustrated in four landmark studies that have provided model implementations of filters, integrators, or both.
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