期刊
CELL
卷 144, 期 3, 页码 402-413出版社
CELL PRESS
DOI: 10.1016/j.cell.2010.12.031
关键词
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资金
- Institut Curie (PIC Division Cellulaire, Polarite et Cancer)
- Agence Nationale pour la Recherche
- Fondation de France
- Association Francaise contre les Myopathies
- National Health and Medical Research Council of Australia
- Australian Research Council
- NIH [HL83249, HL92085]
- Institut Curie
- Association pour la Recherche sur le Cancer
- Grants-in-Aid for Scientific Research [23310087] Funding Source: KAKEN
The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin-and ATP-independent cell response that buffers membrane tension surges during mechanical stress. Conversely, stress release leads to complete caveola reassembly in an actin-and ATP-dependent process. The absence of a functional caveola reservoir in myotubes from muscular dystrophic patients enhanced membrane fragility under mechanical stress. Our findings support a new role for caveolae as a physiological membrane reservoir that quickly accommodates sudden and acute mechanical stresses.
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