期刊
CELL
卷 147, 期 3, 页码 498-508出版社
CELL PRESS
DOI: 10.1016/j.cell.2011.10.011
关键词
-
资金
- international Human Frontier Science Program Organization
- National Institute of Neurological Disorders and Stroke [K99NS075216, R37NS27036]
- Ludwig Institute for Cancer Research
Misfolded proteins accumulating in several neurodegenerative diseases (including Alzheimer, Parkinson, and Huntington diseases) can cause aggregation of their native counterparts through a mechanism similar to the infectious prion protein's induction of a pathogenic conformation onto its cellular isoform. Evidence for such a prion-like mechanism has now spread to the main misfolded proteins, SOD1 and TDP-43, implicated in amyotrophic lateral sclerosis (ALS). The major neurodegenerative diseases may therefore have mechanistic parallels for non-cell-autonomous spread of disease within the nervous system.
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