期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 92, 期 1, 页码 21-26出版社
JOHN WILEY & SONS INC
DOI: 10.1002/jps.10265
关键词
Caco-2, MDR1-MDCK, and wild-type MDCK cells; robotics; PEG-300; P-glycoprotein
资金
- NIGMS NIH HHS [GM 59931, GM 08359] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM059931, T32GM008359] Funding Source: NIH RePORTER
Previous studies in our laboratories have shown that commonly used polyethoxylated pharmaceutical excipients inhibit P-glycoprotein activity in cell culture models of the intestinal mucosa. The results presented in this technical note show that the TECAN Genesis(TM) robotic workstation can be utilized to automate cellular transport studies for evaluating excipient effects on P-glycoprotein activity in vitro and for estimating the permeation of drug-like molecules across cell monolayers. (C) 2002 Wiley-Liss, Inc.
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