期刊
CELL
卷 147, 期 3, 页码 653-665出版社
CELL PRESS
DOI: 10.1016/j.cell.2011.10.012
关键词
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资金
- Gatsby Charitable Foundation
- NIH [R01-CA31534, R01-NS033245, P01-NS055923]
- Marie Betzer Morrow endowment
- ProjectALS/P2ALS
- Wellcome Trust
- NYSTEM
- Harold and Leila Mathers Foundation
Sensory-motor circuits in the spinal cord are constructed with a fine specificity that coordinates motor behavior, but the mechanisms that direct sensory connections with their motor neuron partners remain unclear. The dorsoventral settling position of motor pools in the spinal cord is known to match the distal-to-proximal position of their muscle targets in the limb, but the significance of invariant motor neuron positioning is unknown. An analysis of sensory-motor connectivity patterns in FoxP1 mutant mice, where motor neuron position has been scrambled, shows that the final pattern of sensory-motor connections is initiated by the projection of sensory axons to discrete dorsoventral domains of the spinal cord without regard for motor neuron subtype or, indeed, the presence of motor neurons. By implication, the clustering and dorsoventral settling position of motor neuron pools serve as a determinant of the pattern of sensory input specificity and thus motor coordination.
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