期刊
CELL
卷 140, 期 6, 页码 883-899出版社
CELL PRESS
DOI: 10.1016/j.cell.2010.01.025
关键词
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资金
- Crohn's and Colitis Foundation of America (CCFA) [1762]
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Association for International Cancer Research
- National Institutes of Health
- American Association for Cancer Research
Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention.
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