期刊
CELL
卷 143, 期 2, 页码 187-190出版社
CELL PRESS
DOI: 10.1016/j.cell.2010.09.033
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R01 GM063692, R01 GM063692-08] Funding Source: Medline
Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL) that can be covalently attached to both host and viral proteins. Here we review recent advances toward understanding the role and mechanism of ISG15 modification in antiviral defense.
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