期刊
CELL
卷 141, 期 4, 页码 559-563出版社
CELL PRESS
DOI: 10.1016/j.cell.2010.04.033
关键词
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资金
- NIH [R01 GM081549, R01 GM085442]
- Endowed Scholars program at UT Southwestern Medical Center
- Welch Foundation [I-1619, I-1644]
- Rita Allen Foundation
- Mary Kay Ash Charitable Foundation
A central challenge of biology is to understand how individual cells process information and respond to perturbations. Much of our knowledge is based on ensemble measurements. However, cell-to-cell differences are always present to some degree in any cell population, and the ensemble behaviors of a population may not represent the behaviors of any individual cell. Here, we discuss examples of when heterogeneity cannot be ignored and describe practical strategies for analyzing and interpreting cellular heterogeneity.
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