期刊
ANALYTICAL LETTERS
卷 36, 期 3, 页码 563-576出版社
MARCEL DEKKER INC
DOI: 10.1081/AL-120018244
关键词
titanium dioxide; inductively coupled plasma optical emission spectrometry; open-vessel microwave digestion; high-throughput; rodent tissues; lung tissue; lymph node tissue
There is a need to determine the tissue burdens of inhaled titanium dioxide due to the widespread industrial use of this, compound. A high-throughput method for the determination of TiO2 as titanium in rodent lung and lung-associated lymph node tissues by inductively coupled plasma optical emission spectrometry (ICP-OES) was developed and, validated. Samples were digested in open-vessel, disposable centrifuge tubes in the presence of nitric and hydrofluoric acids. The deter-mined method quantitation limit (MQL) was 4.2 mug TiO2/g tissue. Replicate control samples prepared at this level were determined with a high level of accuracy (100%) and precision (2% RSD). After validation, the described method was applied to determine the concentration of TiO2 (as titanium) in 600 rodent tissue samples spanning a 16-month time period. During this time period, laboratory control samples (n = 48) were analyzed to assess the long-term precision and accuracy of the method. The average recovery of titanium in these samples was 102 +/- 4.8 %.
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