期刊
CELL
卷 143, 期 6, 页码 924-937出版社
CELL PRESS
DOI: 10.1016/j.cell.2010.11.015
关键词
-
资金
- National Institutes of Health [GM-044794]
Meiotic double-strand break (DSB)-initiated recombination must occur between homologous maternal and paternal chromosomes (homolog bias), even though sister chromatids are present. Through physical recombination analyses, we show that sister cohesion, normally mediated by meiotic cohesin Rec8, promotes sister bias; that meiosis-specific axis components Red1/Mek1kinase counteract this effect, thereby satisfying an essential precondition for homolog bias; and that other components, probably recombinosome-related, directly ensure homolog partner selection. Later, Rec8 acts positively to ensure maintenance of bias. These complexities mirror opposing dictates for global sister cohesion versus local separation and differentiation of sisters at recombination sites. Our findings support DSB formation within axis-tethered recombinosomes containing both sisters and ensuing programmed sequential release of first and second DSB ends. First-end release would create a homology-searching tentacle. Rec8 and Red1/Mek1 also independently license recombinational progression and abundantly localize to different domains. These domains could comprise complementary environments that integrate inputs from DSB repair and mitotic chromosome morphogenesis into the complete meiotic program.
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