期刊
CELL
卷 143, 期 1, 页码 111-121出版社
CELL PRESS
DOI: 10.1016/j.cell.2010.09.027
关键词
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资金
- Research Foundation Flanders
- Ministry of Education of the Czech Republic [LC06034]
- Ministerio de Educacion y Ciencia [BFU2005-00071]
- Agency for Innovation by Science and Technology
- HFSP long-term
- Marie Curie IEF
- National Institute of General Medical Sciences [GM65989]
- Department of Energy [DE-FG02-05er15671]
- National Science Foundation [MCB0718202, 0723515]
- NWO-VENI
- [ATLF 142-2007]
Spatial distribution of the plant hormone auxin regulates multiple aspects of plant development. These self-regulating auxin gradients are established by the action of PIN auxin transporters, whose activity is regulated by their constitutive cycling between the plasma membrane and endosomes. Here, we show that auxin signaling by the auxin receptor AUXIN-BINDING PROTEIN 1 (ABP1) inhibits the clathrin-mediated internalization of PIN proteins. ABP1 acts as a positive factor in clathrin recruitment to the plasma membrane, thereby promoting endocytosis. Auxin binding to ABP1 interferes with this action and leads to the inhibition of clathrin-mediated endocytosis. Our study demonstrates that ABP1 mediates a nontranscriptional auxin signaling that regulates the evolutionarily conserved process of clathrin-mediated endocytosis and suggests that this signaling may be essential for the developmentally important feedback of auxin on its own transport.
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