期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 3, 期 1, 页码 11-16出版社
BLACKWELL MUNKSGAARD
DOI: 10.1034/j.1600-6143.2003.30103.x
关键词
HLA antigen; HLA-G; non classical; tolerance; transplantation
The human MHC class I molecule HLA-G has long been known as a molecule selectively expressed by cytotro-phoblastic cells. By inhibiting the cytolytic function of decidual NK cells, HLA-G protects the HLA-A and -B negative semiallogeneic embryonic tissue against the mother's immune system. In the light of this immunosuppressive function, the role of HLA-G in transplantation was investigated. We will review here recently published data on this topic, showing that expression of HLA-G affects the responsive capacity of the immune system, might directly participate in graft acceptation, and should be taken into account for the monitoring of transplantation patients.
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