期刊
NATURE REVIEWS CANCER
卷 3, 期 1, 页码 35-45出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc971
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- NATIONAL CANCER INSTITUTE [P30CA008748] Funding Source: NIH RePORTER
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.
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