期刊
CELL
卷 136, 期 4, 页码 642-655出版社
CELL PRESS
DOI: 10.1016/j.cell.2009.01.035
关键词
-
资金
- National Institutes of Health [GM077581, GM068743, GM072830]
Over the last decade, similar to 20-30 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAs short interfering RNAs (siRNAs) and microRNAs (miRNAs)-act in both somatic and germline lineages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids. Recent advances have revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access. Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据