期刊
CELL
卷 137, 期 4, 页码 609-622出版社
CELL PRESS
DOI: 10.1016/j.cell.2009.04.050
关键词
-
资金
- NIH/NCI
- Leukemia and Lymphoma Society
- Ellison Medical Foundation
The traditional view of p53 activation includes three steps-p53 stabilization, DNA binding, and transcriptional activation. However, recent studies indicate that each step of p53 activation is more complex than originally anticipated. Moreover, both genetic studies in mice and in vitro studies with purified components suggest that the classical model may not be sufficient to explain all aspects of p53 activation in vivo. To reconcile these differences, we propose that antirepression, the release of p53 from repression by factors such as Mdm2 and MdmX, is a key step in the physiological activation of p53.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据