期刊
CELL
卷 137, 期 6, 页码 1001-1004出版社
CELL PRESS
DOI: 10.1016/j.cell.2009.05.023
关键词
-
资金
- NIH [R01-AI072581, R01-CA134530]
The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappa B. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.
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